The way combat works...every PC trying to attain master would die if they had to go out and fight a mekillot to skill up. With Giuseppe...I had 3 weapon skills mastered, master shield use, easily the most overall-skilled fighter I ever had...defense was amazing...sword/shield/parry all mastered, extremely good agility. One time, I went out sword and shield (his primary fighting style) and I got knocked down to 2hp by a fucking SCRAB with two back-to-back freak neck shots.
In general, big-game hunting wasn't something I would ever do solo even with his skills already at master. Mekillots can nearly one-shot you with a lousy foot hit. If they hit your head or neck as a human, you're fucking dead instantly. With human agility, everything tougher than about a tembo has the ability to fuck your ass up if RNGeezus gives it good agility, good strength, and a couple of good rolls.
The idea isn't to set the bar at 1-in-a-million. 5% or so is probably good enough.