You will die. Period. That's just how these things go. All of the above are good ideas to prolong the life of your pc. As is making it a point to look north, look south, look east, look west, etc, every time you move into a new room outside the gates. Sometimes this will keep you from falling into holes, other times this will keep you from getting too close to aggressive wildlife that WILL come and engage you. Either way, it's a lifesaver.
If you are one of the above classes, you can probably engage with a lot of what's within (on foot) walking distance if you don't get below half your stamina. Sometimes there will be more than one of these things in a room. They will usually gang up on you if they are in a room with you, and that can be painful or deadly. If you get more than, say, 1/5th of your health knocked off in a single round, you want to flee. If you get to below 2/3 health, that's also a bad place to be in the wilds. The stuff you see littering the sands all over usually comes from stuff that you can kill without dying, if it is animal parts. Usually. There are rare exceptions. (Again, this is within let's say, 10-12 rooms of the city)